![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.7b00109/asset/images/medium/jm-2017-00109c_0010.gif)
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry
![Top: Distribution of kappa opioid (7-transmembrane receptor), estrogen,... | Download Scientific Diagram Top: Distribution of kappa opioid (7-transmembrane receptor), estrogen,... | Download Scientific Diagram](https://www.researchgate.net/publication/287122607/figure/fig2/AS:307434192162817@1450309431281/Top-Distribution-of-kappa-opioid-7-transmembrane-receptor-estrogen-and-androgen.png)
Top: Distribution of kappa opioid (7-transmembrane receptor), estrogen,... | Download Scientific Diagram
![Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development | National Institute on Drug Abuse (NIDA) Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development | National Institute on Drug Abuse (NIDA)](https://nida.nih.gov/sites/default/files/che-image-web.jpg)
Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development | National Institute on Drug Abuse (NIDA)
![Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion | Semantic Scholar Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/4d3293c2088da60abdac11b52d2ea3b4ecc4f433/11-Figure2-1.png)
Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion | Semantic Scholar
![Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA) Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)](https://nida.nih.gov/sites/default/files/styles/content_image_medium/public/images/valenza_zamarripa_promo.jpg?itok=HRbtRBEw)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)
![Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics](https://jpet.aspetjournals.org/content/jpet/338/1/92/F9.large.jpg)
Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics
![The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006322319313794-gr1.jpg)
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect
![Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications - ScienceDirect Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2666328722000360-gr1.jpg)
Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications - ScienceDirect
![Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0278584615000020-fx1.jpg)
Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect
![Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway | Cell Communication and Signaling | Full Text Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway | Cell Communication and Signaling | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12964-022-00833-3/MediaObjects/12964_2022_833_Figa_HTML.png)